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Contrave is really a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which are made up of many active ingredient, which might make them more potent and safer. Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular will be the fact that at the time of right now there aren't long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. 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